Project Information

• Status: waiting for further submissions by an international team including researchers from HUJI (Amiram Goldblum, Yossi Buganim, Ofra Benny), Hadassah (Assaf Ben-Meir), Wellcome Sanger Institute Hinxton UK (Gavin Wright), and University of Toronto (Jeffrey Lee).

Non-hormonal Contraceptives or "on-demand contraceptives": is a typical project of blocking protein-protein interactions emerging from A single protein in each side of the sperm and the oocyte

We identified by docking a few candidates. Two of them show inhibition in IVF experiments of mice oocytes/sperm and hamster oocyte with human sperm, but in too high concentrations. This project was supported for two and a half years by "Bill and Melinda Gates Foundation" and is currently extended to include crystallography and direct protein-protein binding assays.